Monospecific clonal antibodies

ABCscientific, in collaboration with DB BIOTECH, an IVD certified service company, is focused on the design and production of high quality rabbit clonal antibodies developed by a novel „in vitro cloning technology“ which is the original invention of the company. In vitro cloning technology developed by DBB enables the preparation of a pure immunoglobulin fraction corresponding to a single clone of B lymphocytes. The obtained immunoglobulin recognizes one single linear epitope on the antigen molecule, therefore this antibody is comparable quality-wise to its monoclonal analogue. Moreover, the influence of the protein tertiary structure – frequently present in epitopes recognized by monoclonal antibodies – is eliminated in immunoglobulins corresponding to the clonal antibody.

• New QUALITY of antibodies on the market made by original technology developed and owned by our partner
• Highest specificity, affinity and avidity for IHC diagnostics (antigen as low as 5ng)
• MONOSPECIFIC, recognizing only the specific linear epitope not conformational as many monoclonal antibodies

What is the difference between monoclonal and clonal antibodies?
Clonal antibodies are monospecific such as monoclonals. The principal difference between these two types of antibodiesis that the clonal antibodies recognize solely very specifically selected linear epitope on the antigen molecule after its detailed proteomic analysis whereas the monoclonal antibodies recognize very often steric epitopes that frequently change their conformation during tissue preparation, protein extraction, etc., making the corresponding monoclonal antibody unspecific, less avid and in extreme cases not functional.

Why are clonal antibodies produced by original in vitro cloning technology exceptional?
Clonal antibodies are exceptional because they recognize their target (epitope) with the highest affinity, avidity and specificity that remains unchanged even after the important changes in conformation of the antigen – such as denaturation during the fixation of the tissue, protein transfer in the case of western blot-related procedures, or as a consequence of the protein-protein interactions.

Custom Production Services

We offer custom services and cooperation on special projects pertaining to the design and production of clonal antibodies against any protein or its
modification whose name, detailed description of the modification or aminoacid sequences are supplied by the project contractor.

• agreement based projects - clearly defined: technical requirements, minimum volumes,price per ml.
• DB Biotech will design several clones for the sametarget and let the client choose the most suitable
• 4-5 months delivery time with detailed protocol and testing

We are proud to present our 90% project success rate.
For further information on our custom projects please contact us.

catalog antibodies available:

OZ-DB001 IHC actin
OZ-DB026 p53
OZ-DB027 CD5
OZ-DB030 CD10 (C-term)
OZ-DB037 kappa light chain (N-term)
OZ-DB038 kappa light chain (C-term)
OZ-DB039 lambda light chain (N-term)
OZ-DB041 CD20
OZ-DB042 CD45
OZ-DB043 CD 205 (RCC, DEC 205) (N-term)
OZ-DB044 CD 205 (RCC, DEC 205) (C-term)
OZ-DB045 CD163
OZ-DB047 PLAP
OZ-DB048 CD 227 (Mucin-1,EMA)
OZ-DB049 Melanosome
OZ-DB050 Melan A
OZ-DB051 cytokeratin 7
OZ-DB053 ER (Estrogen receptor)
OZ-DB055 S-100
OZ-DB057 CD10 (N-term)
OZ-DB059 PR (Progesterone receptor)
OZ-DB060 EBV/LMP-1 (internal region)
OZ-DB061 EBV/LMP-1 (C-term)
OZ-DB062 CD117
OZ-DB064 Bcl-2
OZ-DB066 cyclin D1
OZ-DB070 Ki-67
OZ-DB071 CD1a
OZ-DB082 CD3
OZ-DB085 CD8
OZ-DB089 TTF-1 (N-term)
OZ-DB090 TTF-1 (C-term)
OZ-DB094 C-erb-2 (Her-2/neu)
OZ-DB098 cytokeratin 8
OZ-DB099 cytokeratin 14
OZ-DB100 cytokeratin 16
OZ-DB101 cytokeratin 17
OZ-DB102 cytokeratin 18
OZ-DB103 cytokeratin 19
OZ-DB107 c4-d complement